Augmentation of Pectoral Fin Teratogenicity by Thalidomide in Human Cytochrome P450 3A-Expressing Zebrafish

• Main Authors: Wenjing Dong (Author), Ippo Akasaka (Author), Akifumi Komiyama (Author), Tatsuro Nakamura (Author), Naohiro Mizoguchi (Author), Tasuku Nawaji (Author), Shinichi Ikushiro (Author), Makoto Kobayashi (Author), Hiroki Teraoka (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pharmacological and toxicological effects of active metabolites of enzymes including cytochrome P450 (CYP) are important. While it has been believed for a long time that thalidomide causes characteristic limb malformation only in rabbits and primates including humans, the involvement of their CY...