Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening

Trypanothione synthetase (TryS) catalyses the synthesis of N1,N8-bis(glutathionyl)spermidine (trypanothione), which is the main low molecular mass thiol supporting several redox functions in trypanosomatids. TryS attracts attention as molecular target for drug development against pathogens causing s...

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Main Authors: Diego Benítez (Author), Jaime Franco (Author), Florencia Sardi (Author), Alejandro Leyva (Author), Rosario Durán (Author), Gahee Choi (Author), Gyongseon Yang (Author), Taehee Kim (Author), Namyoul Kim (Author), Jinyeong Heo (Author), Kideok Kim (Author), Honggun Lee (Author), Inhee Choi (Author), Constantin Radu (Author), David Shum (Author), Joo Hwan No (Author), Marcelo A. Comini (Author)
Format: Book
Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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