Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8

Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8

The cytochrome P450, CYP2C8, metabolises more than 60 clinically used drugs as well as endogenous substances including retinoic acid and arachidonic acid. However predictive factors for interindividual variability in the efficacy and toxicity of CYP2C8 drug substrates are essentially lacking. Recent...

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Bibliographic Details
Main Authors: Maria eThomas (Author), Stefan eWinter (Author), Britta eKlumpp (Author), Miia eTurpeinen (Author), Kathrin eKlein (Author), Matthias eSchwab (Author), Ulrich M Zanger (Author)
Format: Book
Published: Frontiers Media S.A., 2015-11-01T00:00:00Z.
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3rd Floor Main Library

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