PBF509, an Adenosine A2A Receptor Antagonist With Efficacy in Rodent Models of Movement Disorders

• Main Authors: Fabiana Núñez (Author), Jaume Taura (Author), Juan Camacho (Author), Marc López-Cano (Author), Víctor Fernández-Dueñas (Author), Naomi Castro (Author), Julio Castro (Author), Francisco Ciruela (Author)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Adenosine A2A receptor (A2AR) antagonists have emerged as complementary non-dopaminergic drugs to alleviate Parkinson's disease (PD) symptomatology. Here, we characterize a novel non-xhantine non-furan A2AR antagonist, PBF509, as a potential pro-dopaminergic drug for PD management. First, PBF50...