Small Molecule Docking Supports Broad and Narrow Spectrum Potential for the Inhibition of the Novel Antibiotic Target Bacterial Pth1

Small Molecule Docking Supports Broad and Narrow Spectrum Potential for the Inhibition of the Novel Antibiotic Target Bacterial Pth1

Peptidyl-tRNA hydrolases (Pths) play ancillary yet essential roles in protein biosynthesis by recycling peptidyl-tRNA. In E. coli, inhibition of bacterial Pth1 leads to accumulation of peptidyl-tRNA, depletion of aminoacyl-tRNA, and cell death. Eukaryotes have multiple Pths and Pth1 knock out was sh...

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Main Authors: Paul P. Ferguson (Author), W. Blake Holloway (Author), William N. Setzer (Author), Hana McFeeters (Author), Robert L. McFeeters (Author)
Format: Book
Published: MDPI AG, 2016-05-01T00:00:00Z.
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3rd Floor Main Library

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