Structural and Functional Analysis of CEX Fractions Collected from a Novel Avastin^® Biosimilar Candidate and Its Innovator: A Comparative Study

• Main Authors: Busra Gurel (Author), Melike Berksoz (Author), Eda Capkin (Author), Ayhan Parlar (Author), Meltem Corbacioglu Pala (Author), Aylin Ozkan (Author), Yılmaz Capan (Author), Duygu Emine Daglikoca (Author), Meral Yuce (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Avastin^® is a humanized recombinant monoclonal antibody used to treat cancer by targeting VEGF-A to inhibit angiogenesis. SIMAB054, an Avastin^® biosimilar candidate developed in this study, showed a different charge variant profile than its innovator. Th...