Revisiting the central metabolism of the bloodstream forms of Trypanosoma brucei: production of acetate in the mitochondrion is essential for parasite viability.

• Main Authors: Muriel Mazet (Author), Pauline Morand (Author), Marc Biran (Author), Guillaume Bouyssou (Author), Pierrette Courtois (Author), Sylvie Daulouède (Author), Yoann Millerioux (Author), Jean-Michel Franconi (Author), Philippe Vincendeau (Author), Patrick Moreau (Author), Frédéric Bringaud (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: The bloodstream forms of Trypanosoma brucei, the causative agent of sleeping sickness, rely solely on glycolysis for ATP production. It is generally accepted that pyruvate is the major end-product excreted from glucose metabolism by the proliferative long-slender bloodstream forms of the...