The Delivery of α1-Antitrypsin Therapy Through Transepidermal Route: Worthwhile to Explore

• Main Authors: Srinu Tumpara (Author), Beatriz Martinez-Delgado (Author), Gema Gomez-Mariano (Author), Bin Liu (Author), David S. DeLuca (Author), Elena Korenbaum (Author), Danny Jonigk (Author), Frank Jugert (Author), Florian M. Wurm (Author), Maria J. Wurm (Author), Tobias Welte (Author), Sabina Janciauskiene (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human α1-antitrypsin (AAT) is an abundant acute phase glycoprotein expressing anti-protease and immunomodulatory activities, and is used as a biopharmaceutical to treat patients with inherited AAT deficiency. The pleiotropic properties of AAT provide a rationale for using this therapy outside of inh...