Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing

• Main Authors: Qin Xia (Author), Penglin Li (Author), José C. Casas-Martinez (Author), Antonio Miranda-Vizuete (Author), Emma McDermott (Author), Peter Dockery (Author), Katarzyna Goljanek-Whysall (Author), Brian McDonagh (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: A decline in mitochondrial function and increased susceptibility to oxidative stress is a hallmark of ageing. Exercise endogenously generates reactive oxygen species (ROS) in skeletal muscle and promotes mitochondrial remodelling resulting in improved mitochondrial function. It is unclea...