The t(14;18) translocation is absent from endothelial and follicular dendritic cells of follicular lymphoma (FL) and shows heterogeneous presence in preserved FL mantle zones

• Main Authors: Perikles Kosmidis (Author), Barbara Mankel (Author), Falko Fend (Author), Patrick Adam (Author)
• 格式: 圖書
• 出版: BMC, 2018-05-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Abstract Background The translocation t(14;18)(q32;q21) is the genetic hallmark of follicular lymphoma (FL) and can be observed in 85-90% of cases. Whether the translocation is restricted to cells with germinal center B-cell phenotype or can be observed in other cell types of the microenvironment re...