Modulation of Adenosine-Induced Responses in the Guinea-Pig Trachea During Long-Term Caffeine Treatment: Possible Role of Epithelium

• Main Authors: László Brugós (Author), Rudolf Gesztelyi (Author), Judit Zsuga (Author), Ágnes Cseppento (Author), Ilona Benko (Author), Zoltán Galajda (Author), György Deák (Author), Sándor Sipka (Author), Tamás Roszer (Author), Péter Kovács (Author), Mária Szilasi (Author), István Édes (Author), András József Szentmiklósi (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The responses to adenosine were studied on isolated, methacholine-precontracted tracheal strips of guinea pigs in the course of long-term caffeine or solvent treatment. Guinea pigs were fed caffeine for 10 weeks (average serum caffeine concentration: 39.1 ± 3.9 µM). In epithelium-intact tracheal pre...