Unlocking the Antibiofilm Potential of Natural Compounds by Targeting the NADH:quinone Oxidoreductase WrbA

• Main Authors: Alessandro Ratti (Author), Enrico M. A. Fassi (Author), Fabio Forlani (Author), Maurizio Zangrossi (Author), Matteo Mori (Author), Francesca Cappitelli (Author), Gabriella Roda (Author), Stefania Villa (Author), Federica Villa (Author), Giovanni Grazioso (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Biofilm-dwelling cells endure adverse conditions, including oxidative imbalances. The NADH:quinone oxidoreductase enzyme WrbA has a crucial role in the mechanism of action of antibiofilm molecules such as ellagic and salicylic acids. This study aimed to exploit the potential of the WrbA scaffold as...