Population pharmacokinetics modeling and exposure‐response analyses of cemiplimab in patients with recurrent or metastatic cervical cancer

• Main Authors: Jenny‐Hoa Nguyen (Author), Daniel Epling (Author), Nancy Dolphin (Author), Anne Paccaly (Author), Daniela Conrado (Author), John D. Davis (Author), Nidal Al‐Huniti (Author)
• Format: Book
• Published: Wiley, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract A population pharmacokinetic (PopPK) model was previously developed for cemiplimab in patients with solid tumors, including advanced cutaneous squamous cell carcinoma (CSCC). Here, we update the existing PopPK model and characterize exposure‐response relationships using efficacy and safety...