Roflumilast Powders for Chronic Obstructive Pulmonary Disease: Formulation Design and the Influence of Device, Inhalation Flow Rate, and Storage Relative Humidity on Aerosolization

• Main Authors: Mohammad A. M. Momin (Author), Bishal Raj Adhikari (Author), Shubhra Sinha (Author), Ian Larson (Author), Shyamal C. Das (Author)
• 格式: 圖書
• 出版: MDPI AG, 2021-08-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Roflumilast is currently administered orally to control acute exacerbations in chronic obstructive pulmonary disease (COPD). However, side effects such as gastrointestinal disturbance and weight loss have limited its application. This work aimed to develop an inhalable roflumilast formulation to red...