Nitro-benzylideneoxymorphone, a bifunctional mu and delta opioid receptor ligand with high mu opioid receptor efficacy

• Main Authors: Keith M. Olson (Author), Andrea L. Devereaux (Author), Payal Chatterjee (Author), Savanah L. Saldaña-Shumaker (Author), Amanda Shafer (Author), Adam Plotkin (Author), Ram Kandasamy (Author), Alexander D. MacKerell (Author), John R. Traynor (Author), Christopher W. Cunningham (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: There is a major societal need for analgesics with less tolerance, dependence, and abuse liability. Preclinical rodent studies suggest that bifunctional ligands with both mu (MOPr) and delta (DOPr) opioid peptide receptor activity may produce analgesia with reduced tolerance and other...