A CRISPR-guided mutagenic DNA polymerase strategy for the detection of antibiotic-resistant mutations in M. tuberculosis

A CRISPR-guided mutagenic DNA polymerase strategy for the detection of antibiotic-resistant mutations in M. tuberculosis

A sharp increase in multidrug-resistant tuberculosis (MDR-TB) threatens human health. Spontaneous mutation in essential gene confers an ability of Mycobacterium tuberculosis resistance to anti-TB drugs. However, conventional laboratory strategies for identification and prediction of the mutations in...

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Main Authors: Siyuan Feng (Author), Lujie Liang (Author), Cong Shen (Author), Daixi Lin (Author), Jiachen Li (Author), Lingxuan Lyu (Author), Wanfei Liang (Author), Lan-lan Zhong (Author), Gregory M. Cook (Author), Yohei Doi (Author), Cha Chen (Author), Guo-bao Tian (Author)
Format: Book
Published: Elsevier, 2022-09-01T00:00:00Z.
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