Association of mitochondrial DNA copy number with cardiometabolic diseases

• Main Authors: Xue Liu (Author), Ryan J. Longchamps (Author), Kerri L. Wiggins (Author), Laura M. Raffield (Author), Lawrence F. Bielak (Author), Wei Zhao (Author), Achilleas Pitsillides (Author), Thomas W. Blackwell (Author), Jie Yao (Author), Xiuqing Guo (Author), Nuzulul Kurniansyah (Author), Bharat Thyagarajan (Author), Nathan Pankratz (Author), Stephen S. Rich (Author), Kent D. Taylor (Author), Patricia A. Peyser (Author), Susan R. Heckbert (Author), Sudha Seshadri (Author), L. Adrienne Cupples (Author), Eric Boerwinkle (Author), Megan L. Grove (Author), Nicholas B. Larson (Author), Jennifer A. Smith (Author), Ramachandran S. Vasan (Author), Tamar Sofer (Author), Annette L. Fitzpatrick (Author), Myriam Fornage (Author), Jun Ding (Author), Adolfo Correa (Author), Goncalo Abecasis (Author), Bruce M. Psaty (Author), James G. Wilson (Author), Daniel Levy (Author), Jerome I. Rotter (Author), Joshua C. Bis (Author), Claudia L. Satizabal (Author), Dan E. Arking (Author), Chunyu Liu (Author)
• Format: Book
• Published: Elsevier, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Mitochondrial DNA (mtDNA) is present in multiple copies in human cells. We evaluated cross-sectional associations of whole-blood mtDNA copy number (CN) with several cardiometabolic disease traits in 408,361 participants of multiple ancestries in TOPMed and UK Biobank. Age showed a threshold...