Association of mitochondrial DNA copy number with cardiometabolic diseases

• Main Authors: Xue Liu (Author), Ryan J. Longchamps (Author), Kerri L. Wiggins (Author), Laura M. Raffield (Author), Lawrence F. Bielak (Author), Wei Zhao (Author), Achilleas Pitsillides (Author), Thomas W. Blackwell (Author), Jie Yao (Author), Xiuqing Guo (Author), Nuzulul Kurniansyah (Author), Bharat Thyagarajan (Author), Nathan Pankratz (Author), Stephen S. Rich (Author), Kent D. Taylor (Author), Patricia A. Peyser (Author), Susan R. Heckbert (Author), Sudha Seshadri (Author), L. Adrienne Cupples (Author), Eric Boerwinkle (Author), Megan L. Grove (Author), Nicholas B. Larson (Author), Jennifer A. Smith (Author), Ramachandran S. Vasan (Author), Tamar Sofer (Author), Annette L. Fitzpatrick (Author), Myriam Fornage (Author), Jun Ding (Author), Adolfo Correa (Author), Goncalo Abecasis (Author), Bruce M. Psaty (Author), James G. Wilson (Author), Daniel Levy (Author), Jerome I. Rotter (Author), Joshua C. Bis (Author), Claudia L. Satizabal (Author), Dan E. Arking (Author), Chunyu Liu (Author)
• Format: Book
• Published: Elsevier, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Summary: Mitochondrial DNA (mtDNA) is present in multiple copies in human cells. We evaluated cross-sectional associations of whole-blood mtDNA copy number (CN) with several cardiometabolic disease traits in 408,361 participants of multiple ancestries in TOPMed and UK Biobank. Age showed a threshold association with mtDNA CN: each additional 10 years of age was associated with a 0.03 SD higher level of mtDNA CN (p = 0.0014) among younger participants (younger than 65 years) versus a 0.14 SD lower level of mtDNA CN (p = 1.82 × 10−13) among older participants (65 years and older). At lower mtDNA CN levels, we found age-independent associations with increased odds of obesity (p = 5.6 × 10−238), hypertension (p = 2.8 × 10−50), diabetes (p = 3.6 × 10−7), and hyperlipidemia (p = 6.3 × 10−56). The observed decline in mtDNA CN after 65 years of age may be a key to understanding age-related diseases.

Item Description

2666-979X
10.1016/j.xgen.2021.100006