Association of mitochondrial DNA copy number with cardiometabolic diseases
Summary: Mitochondrial DNA (mtDNA) is present in multiple copies in human cells. We evaluated cross-sectional associations of whole-blood mtDNA copy number (CN) with several cardiometabolic disease traits in 408,361 participants of multiple ancestries in TOPMed and UK Biobank. Age showed a threshold...
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| Format: | Book |
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Elsevier,
2021-10-01T00:00:00Z.
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| 001 | doaj_d67cf2b72fdc44dcad48f49e84ac8b65 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Xue Liu |e author |
| 700 | 1 | 0 | |a Ryan J. Longchamps |e author |
| 700 | 1 | 0 | |a Kerri L. Wiggins |e author |
| 700 | 1 | 0 | |a Laura M. Raffield |e author |
| 700 | 1 | 0 | |a Lawrence F. Bielak |e author |
| 700 | 1 | 0 | |a Wei Zhao |e author |
| 700 | 1 | 0 | |a Achilleas Pitsillides |e author |
| 700 | 1 | 0 | |a Thomas W. Blackwell |e author |
| 700 | 1 | 0 | |a Jie Yao |e author |
| 700 | 1 | 0 | |a Xiuqing Guo |e author |
| 700 | 1 | 0 | |a Nuzulul Kurniansyah |e author |
| 700 | 1 | 0 | |a Bharat Thyagarajan |e author |
| 700 | 1 | 0 | |a Nathan Pankratz |e author |
| 700 | 1 | 0 | |a Stephen S. Rich |e author |
| 700 | 1 | 0 | |a Kent D. Taylor |e author |
| 700 | 1 | 0 | |a Patricia A. Peyser |e author |
| 700 | 1 | 0 | |a Susan R. Heckbert |e author |
| 700 | 1 | 0 | |a Sudha Seshadri |e author |
| 700 | 1 | 0 | |a L. Adrienne Cupples |e author |
| 700 | 1 | 0 | |a Eric Boerwinkle |e author |
| 700 | 1 | 0 | |a Megan L. Grove |e author |
| 700 | 1 | 0 | |a Nicholas B. Larson |e author |
| 700 | 1 | 0 | |a Jennifer A. Smith |e author |
| 700 | 1 | 0 | |a Ramachandran S. Vasan |e author |
| 700 | 1 | 0 | |a Tamar Sofer |e author |
| 700 | 1 | 0 | |a Annette L. Fitzpatrick |e author |
| 700 | 1 | 0 | |a Myriam Fornage |e author |
| 700 | 1 | 0 | |a Jun Ding |e author |
| 700 | 1 | 0 | |a Adolfo Correa |e author |
| 700 | 1 | 0 | |a Goncalo Abecasis |e author |
| 700 | 1 | 0 | |a Bruce M. Psaty |e author |
| 700 | 1 | 0 | |a James G. Wilson |e author |
| 700 | 1 | 0 | |a Daniel Levy |e author |
| 700 | 1 | 0 | |a Jerome I. Rotter |e author |
| 700 | 1 | 0 | |a Joshua C. Bis |e author |
| 700 | 1 | 0 | |a Claudia L. Satizabal |e author |
| 700 | 1 | 0 | |a Dan E. Arking |e author |
| 700 | 1 | 0 | |a Chunyu Liu |e author |
| 245 | 0 | 0 | |a Association of mitochondrial DNA copy number with cardiometabolic diseases |
| 260 | |b Elsevier, |c 2021-10-01T00:00:00Z. | ||
| 500 | |a 2666-979X | ||
| 500 | |a 10.1016/j.xgen.2021.100006 | ||
| 520 | |a Summary: Mitochondrial DNA (mtDNA) is present in multiple copies in human cells. We evaluated cross-sectional associations of whole-blood mtDNA copy number (CN) with several cardiometabolic disease traits in 408,361 participants of multiple ancestries in TOPMed and UK Biobank. Age showed a threshold association with mtDNA CN: each additional 10 years of age was associated with a 0.03 SD higher level of mtDNA CN (p = 0.0014) among younger participants (younger than 65 years) versus a 0.14 SD lower level of mtDNA CN (p = 1.82 × 10−13) among older participants (65 years and older). At lower mtDNA CN levels, we found age-independent associations with increased odds of obesity (p = 5.6 × 10−238), hypertension (p = 2.8 × 10−50), diabetes (p = 3.6 × 10−7), and hyperlipidemia (p = 6.3 × 10−56). The observed decline in mtDNA CN after 65 years of age may be a key to understanding age-related diseases. | ||
| 546 | |a EN | ||
| 690 | |a mitochondrial DNA copy number | ||
| 690 | |a cardiometabolic disease | ||
| 690 | |a whole-genome sequencing | ||
| 690 | |a whole-exom sequencing | ||
| 690 | |a aging | ||
| 690 | |a white blood cell counts | ||
| 690 | |a Genetics | ||
| 690 | |a QH426-470 | ||
| 690 | |a Internal medicine | ||
| 690 | |a RC31-1245 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Cell Genomics, Vol 1, Iss 1, Pp 100006- (2021) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S2666979X21000069 | |
| 787 | 0 | |n https://doaj.org/toc/2666-979X | |
| 856 | 4 | 1 | |u https://doaj.org/article/d67cf2b72fdc44dcad48f49e84ac8b65 |z Connect to this object online. |