Drug interactions between ALK inhibitors and warfarin with concurrent use of bucolome: a case report

• Main Authors: Takashi Kato (Author), Yusuke Kunimoto (Author), Manabu Kitagawa (Author), Yuichiro Asai (Author), Tomoko Kimyo (Author), Hiromasa Nakata (Author), Mamoru Takahashi (Author), Hirofumi Chiba (Author), Hiroki Takahashi (Author), Atsushi Miyamoto (Author), Masahide Fukudo (Author)
• Format: Book
• Published: BMC, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Alectinib, crizotinib, and ceritinib, are anaplastic lymphoma kinase-tyrosine kinase inhibitors (ALK-TKIs) that exhibit high protein binding, and their metabolism is associated with the cytochrome P450 (CYP) isoenzymes 2C9 or 3A4. The plasma protein binding rate of warfarin, whic...