Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation

• Main Authors: Mie Kristensen (Author), Krzysztof Kucharz (Author), Eduardo Felipe Alves Fernandes (Author), Kristian Strømgaard (Author), Morten Schallburg Nielsen (Author), Hans Christian Cederberg Helms (Author), Anders Bach (Author), Malte Ulrikkaholm Tofte-Hansen (Author), Blanca Irene Aldana Garcia (Author), Martin Lauritzen (Author), Birger Brodin (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Novel stroke therapies are needed. Inhibition of the interaction between the postsynaptic density-95 (PSD-95)/disc large/ZO-1 (PDZ) domains of PSD-95 and the <i>N</i>-methyl-D-aspartate (NMDA) receptor has been suggested as a strategy for relieving neuronal damage. The peptides NR2B9c an...