Relationships Between Allopurinol Dose, Oxypurinol Concentration and Urate‐Lowering Response-In Search of a Minimum Effective Oxypurinol Concentration

• Main Authors: Lisa K. Stamp (Author), Peter T. Chapman (Author), Murray Barclay (Author), Anne Horne (Author), Christopher Frampton (Author), Tony R. Merriman (Author), Daniel F. B. Wright (Author), Jill Drake (Author), Nicola Dalbeth (Author)
• Format: Book
• Published: Wiley, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aims of this study were to determine factors that predict serum urate (SU) lowering response to allopurinol and the conversion of allopurinol to oxypurinol, and to determine a minimum therapeutic oxypurinol concentration. Data from 129 participants in a 24‐month open, randomized, controlled, par...