A Simple Flow Injection Analysis-Tandem Mass Spectrometry Method to Reduce False Positives of C5-Acylcarnitines Due to Pivaloylcarnitine Using Reference Ions

• Main Authors: Takanari Hattori (Author), Yoshitomo Notsu (Author), Misa Tanaka (Author), Miki Matsui (Author), Tetsuo Iida (Author), Jun Watanabe (Author), Yoshimitsu Osawa (Author), Seiji Yamaguchi (Author), Shozo Yano (Author), Takeshi Taketani (Author), Hironori Kobayashi (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Flow injection analysis-tandem mass spectrometry (FIA-TMS) has been applied in a first-tier test of newborn screening (NBS). Although isovalerylcarnitine (i-C5), which is a diagnostic indicator of isovaleric acidemia (IVA), is isobaric with pivaloylcarnitine (p-C5), 2-methylbutyrylcarnitine, and n-v...