Single-cell RNA sequencing revealed subclonal heterogeneity and gene signatures of gemcitabine sensitivity in pancreatic cancer

• Main Authors: Zelin Hou (Author), Jiajing Lin (Author), Yuan Ma (Author), Haizhong Fang (Author), Yuwei Wu (Author), Zhijiang Chen (Author), Xianchao Lin (Author), Fengchun Lu (Author), Shi Wen (Author), Xunbin Yu (Author), Heguang Huang (Author), Yu Pan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Resistance to gemcitabine is common and critically limits its therapeutic efficacy in pancreatic ductal adenocarcinoma (PDAC).Methods: We constructed 17 patient-derived xenograft (PDX) models from PDAC patient samples and identified the most notable responder to gemcitabine by screenin...