Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish

• Auteurs principaux: Alexander J. Valvezan (Auteur), Jian Huang (Auteur), Christopher J. Lengner (Auteur), Michael Pack (Auteur), Peter S. Klein (Auteur)
• Format: Livre
• Publié: The Company of Biologists, 2014-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Truncating mutations in adenomatous polyposis coli (APC) are strongly linked to colorectal cancers. APC is a negative regulator of the Wnt pathway and constitutive Wnt activation mediated by enhanced Wnt-β-catenin target gene activation is believed to be the predominant mechanism responsible for APC...