Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish

Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish

Truncating mutations in adenomatous polyposis coli (APC) are strongly linked to colorectal cancers. APC is a negative regulator of the Wnt pathway and constitutive Wnt activation mediated by enhanced Wnt-β-catenin target gene activation is believed to be the predominant mechanism responsible for APC...

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Bibliographic Details
Main Authors: Alexander J. Valvezan (Author), Jian Huang (Author), Christopher J. Lengner (Author), Michael Pack (Author), Peter S. Klein (Author)
Format: Book
Published: The Company of Biologists, 2014-01-01T00:00:00Z.
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3rd Floor Main Library

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