Saliva as a noninvasive sampling matrix for therapeutic drug monitoring of intravenous busulfan in Chinese patients undergoing hematopoietic stem cell transplantation: A prospective population pharmacokinetic and simulation study

• Main Authors: Baohua Xu (Author), Ting Yang (Author), Jianxing Zhou (Author), You Zheng (Author), Jingting Wang (Author), Qingxia Liu (Author), Dandan Li (Author), Yifan Zhang (Author), Maobai Liu (Author), Xuemei Wu (Author)
• Format: Book
• Published: Wiley, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Therapeutic drug monitoring (TDM) of busulfan (BU) is currently performed by plasma sampling in patients undergoing hematopoietic stem cell transplantation (HSCT). Saliva samples are considered a noninvasive TDM matrix. Currently, no salivary population pharmacokinetics (PopPKs) model for B...