Diabetes Upregulates Oxidative Stress and Downregulates Cardiac Protection to Exacerbate Myocardial Ischemia/Reperfusion Injury in Rats

• 主要な著者: Chen-Yen Chien (著者), Ting-Jui Wen (著者), Yu-Hsiuan Cheng (著者), Yi-Ting Tsai (著者), Chih-Yao Chiang (著者), Chiang-Ting Chien (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2020-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Diabetes exacerbates myocardial ischemia/reperfusion (IR) injury by incompletely understood mechanisms. We explored whether diabetes diminished BAG3/Bcl-2/Nrf-2/HO-1-mediated cardioprotection and overproduced oxidative stress contributing to exaggerated IR injury. Streptozotocin-induced diabetes enh...