Blinded In Silico Drug Trial Reveals the Minimum Set of Ion Channels for Torsades de Pointes Risk Assessment

• Main Authors: Xin Zhou (Author), Yusheng Qu (Author), Elisa Passini (Author), Alfonso Bueno-Orovio (Author), Yang Liu (Author), Hugo M. Vargas (Author), Blanca Rodriguez (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Torsades de Pointes (TdP) is a type of ventricular arrhythmia which could be observed as an unwanted drug-induced cardiac side effect, and it is associated with repolarization abnormalities in single cells. The pharmacological evaluations of TdP risk in previous years mainly focused on the hERG chan...