Small ubiquitin-related modifier (SUMO)ylation of SIRT1 mediates (-)-epicatechin inhibited- differentiation of cardiac fibroblasts into myofibroblasts

• Main Authors: Yingchun Luo (Author), Jing Lu (Author), Zeng Wang (Author), Lu Wang (Author), Guodong Wu (Author), Yuanyuan Guo (Author), Zengxiang Dong (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Context (-)-Epicatechin (EPI) is a crucial substance involved in the protective effects of flavanol-rich foods. Previous studies have indicated EPI has a cardioprotective effect, but the molecular mechanisms in inhibition of cardiac fibrosis are unclear.Objective We evaluated the effect of EPI in pr...