Unveiling the impact of CDK8 on tumor progression: mechanisms and therapeutic strategies

• Main Authors: Xiaomin Yin (Author), Zhilong He (Author), Kun Chen (Author), Kai Ouyang (Author), Changxuan Yang (Author), Jianjun Li (Author), Hailin Tang (Author), Manbo Cai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CDK8 is an important member of the cyclin-dependent kinase family associated with transcription and acts as a key "molecular switch" in the Mediator complex. CDK8 regulates gene expression by phosphorylating transcription factors and can control the transcription process through Mediator c...