Ibudilast-Induced Decreases in Cytosolic Ca2+ Level and Contraction in Rat Aorta

• Main Authors: Takeharu Kaneda (Author), Yasushi Konno (Author), Norimoto Urakawa (Author), Shinjiro Nakajyo (Author), Kazumasa Shimizu (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mechanism by which ibudilast induces vasodilation was examined in isolated endothelium-denuded rat aorta. Ibudilast inhibited the contractions induced by phenylephrine (PE) and high K+ with decrease of [Ca2+]i level in a concentration-dependent manner, to the same degree. 3-Isobutyl-1-methylxant...