Fatal Epileptic Seizures in Mice Having Compromised Glutathione and Ascorbic Acid Biosynthesis

• Үндсэн зохиолчид: Ying Chen (Зохиогч), Katherine D. Holland (Зохиогч), Howard G. Shertzer (Зохиогч), Daniel W. Nebert (Зохиогч), Timothy P. Dalton (Зохиогч)
• Формат: Ном
• Хэвлэсэн: MDPI AG, 2023-02-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Reduced glutathione (GSH) and ascorbic acid (AA) are the two most abundant low-molecular-weight antioxidants in mammalian tissues. <i>Gclm^KO</i> knockout mice lack the gene encoding the modifier subunit of the rate-limiting enzyme in GSH biosynthesis; <i>Gclm...