A Model for Allosteric Communication in Drug Transport by the AcrAB-TolC Tripartite Efflux Pump

• Autori principali: Anya Webber (Autore), Malitha Ratnaweera (Autore), Andrzej Harris (Autore), Ben F. Luisi (Autore), Véronique Yvette Ntsogo Enguéné (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2022-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

RND family efflux pumps are complex macromolecular machines involved in multidrug resistance by extruding antibiotics from the cell. While structural studies and molecular dynamics simulations have provided insights into the architecture and conformational states of the pumps, the path followed by c...