Effects of Postprandial Factors and Second Meal Intake Time on Bioequivalence Investigation of Tadalafil-Loaded Orodispersible Films in Human Volunteers

• Main Authors: Su-Jun Park (Author), Myung-Chul Gil (Author), Bong-Sang Lee (Author), Minji Jung (Author), Beom-Jin Lee (Author)
• Format: Knjiga
• Izdano: MDPI AG, 2024-07-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Tadalafil (TD) has poor water solubility but is well absorbed without affecting food intake when administered orally. Owing to patient adherence and therapeutic characteristics, a TD-loaded orodispersible film (TDF) is preferable. However, the mechanistic role of dietary status on the clinical pharm...