Cancer Microenvironment and Endoplasmic Reticulum Stress Response

• Main Authors: Claudia Giampietri (Author), Simonetta Petrungaro (Author), Silvia Conti (Author), Antonio Facchiano (Author), Antonio Filippini (Author), Elio Ziparo (Author)
• Format: Book
• Published: Hindawi Limited, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Different stressful conditions such as hypoxia, nutrient deprivation, pH changes, or reduced vascularization, potentially able to act as growth-limiting factors for tumor cells, activate the unfolded protein response (UPR). UPR is therefore involved in tumor growth and adaptation to severe environme...