Impact of <i>GSTA1</i> Polymorphisms on Busulfan Oral Clearance in Adult Patients Undergoing Hematopoietic Stem Cell Transplantation

• Main Authors: Veronique Michaud (Author), My Tran (Author), Benoit Pronovost (Author), Philippe Bouchard (Author), Sarah Bilodeau (Author), Karine Alain (Author), Barbara Vadnais (Author), Martin Franco (Author), François Bélanger (Author), Jacques Turgeon (Author)
• Format: Book
• Published: MDPI AG, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Busulfan pharmacokinetics exhibit large inter-subject variability. Our objective was to evaluate the influence of glutathione S-transferase A1 (<i>GSTA1</i>) gene variants on busulfan oral clearance (CLo) in a population of patients undergoing hematopoietic stem cell transpla...