Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult

• Main Authors: Nicole K.H. Yiew (Author), Joel H. Vazquez (Author), Michael R. Martino (Author), Stefanie Kennon-McGill (Author), Jake R. Price (Author), Felicia D. Allard (Author), Eric U. Yee (Author), Alexander J. Layman (Author), Laura P. James (Author), Kyle S. McCommis (Author), Brian N. Finck (Author), Mitchell R. McGill (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Mitochondrial pyruvate is a critical intermediary metabolite in gluconeogenesis, lipogenesis, and NADH production. As a result, the mitochondrial pyruvate carrier (MPC) complex has emerged as a promising therapeutic target in metabolic diseases. Clinical trials are currently underway. How...