Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model

• Glavni autori: Leticia L. Niborski (Autor), Mélanie Paces-Fessy (Autor), Pierbruno Ricci (Autor), Adeline Bourgeois (Autor), Pedro Magalhães (Autor), Maria Kuzma-Kuzniarska (Autor), Celine Lesaulnier (Autor), Martin Reczko (Autor), Edwige Declercq (Autor), Petra Zürbig (Autor), Alain Doucet (Autor), Muriel Umbhauer (Autor), Silvia Cereghini (Autor)
• Format: Knjiga
• Izdano: The Company of Biologists, 2021-05-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Heterozygous mutations in HNF1B cause the complex syndrome renal cysts and diabetes (RCAD), characterized by developmental abnormalities of the kidneys, genital tracts and pancreas, and a variety of renal, pancreas and liver dysfunctions. The pathogenesis underlying this syndrome remains unclear as...