Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model

• Main Authors: Leticia L. Niborski (Author), Mélanie Paces-Fessy (Author), Pierbruno Ricci (Author), Adeline Bourgeois (Author), Pedro Magalhães (Author), Maria Kuzma-Kuzniarska (Author), Celine Lesaulnier (Author), Martin Reczko (Author), Edwige Declercq (Author), Petra Zürbig (Author), Alain Doucet (Author), Muriel Umbhauer (Author), Silvia Cereghini (Author)
• Format: Book
• Published: The Company of Biologists, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heterozygous mutations in HNF1B cause the complex syndrome renal cysts and diabetes (RCAD), characterized by developmental abnormalities of the kidneys, genital tracts and pancreas, and a variety of renal, pancreas and liver dysfunctions. The pathogenesis underlying this syndrome remains unclear as...