Effect of elexacaftor-tezacaftor-ivacaftor on nasal potential difference and lung function in Phe508del rats

• Main Authors: Nicole Reyne (Author), Patricia Cmielewski (Author), Alexandra McCarron (Author), Ronan Smith (Author), Elena Schneider-Futschik (Author), Nina Eikelis (Author), Piraveen Pirakalathanan (Author), David Parsons (Author), Martin Donnelley (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2024-03-01T00:00:00Z.
• Fag: article
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Introduction:Phe508del is the most common cystic fibrosis transmembrane conductance regulator (CFTR) gene variant that results in the recessive genetic disorder cystic fibrosis (CF). The recent development of highly effective CFTR modulator therapies has led to significant health improvements in ind...