Does ethnicity impact CYP2D6 genotype-phenotype relationships?

• Main Authors: Trine Frederiksen (Author), Johan Areberg (Author), Ellen Schmidt (Author), Tore Bjerregaard Stage (Author), Kim Brøsen (Author)
• Format: Bog
• Udgivet: Wiley, 2023-06-01T00:00:00Z.
• Fag: article
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Abstract Polymorphism of the CYP2D6 gene leads to substantial interindividual variability in CYP2D6 enzyme activity. Despite improvements in prediction of CYP2D6 activity based on genotype information, large interindividual variability within CYP2D6 genotypes remains and ethnicity could be a contrib...