Applying the CiPA approach to evaluate cardiac proarrhythmia risk of some antimalarials used off‐label in the first wave of COVID‐19

• Main Authors: Annie Delaunois (Author), Matthew Abernathy (Author), Warren D. Anderson (Author), Kylie A. Beattie (Author), Khuram W. Chaudhary (Author), Julie Coulot (Author), Vitalina Gryshkova (Author), Simon Hebeisen (Author), Mark Holbrook (Author), James Kramer (Author), Yuri Kuryshev (Author), Derek Leishman (Author), Isabel Lushbough (Author), Elisa Passini (Author), Will S. Redfern (Author), Blanca Rodriguez (Author), Eric I. Rossman (Author), Cristian Trovato (Author), Caiyun Wu (Author), Jean‐Pierre Valentin (Author)
• Format: Book
• Published: Wiley, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract We applied a set of in silico and in vitro assays, compliant with the Comprehensive In Vitro Proarrhythmia Assay (CiPA) paradigm, to assess the risk of chloroquine (CLQ) or hydroxychloroquine (OH‐CLQ)‐mediated QT prolongation and Torsades de Pointes (TdP), alone and combined with erythromyc...