Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides

• Hauptverfasser: Zuzana Kohoutova (Verfasst von), David Malinak (Verfasst von), Rudolf Andrys (Verfasst von), Jana Svobodova (Verfasst von), Miroslav Psotka (Verfasst von), Monika Schmidt (Verfasst von), Lukas Prchal (Verfasst von), Kamil Musilek (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Schlagworte: article
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The organophosphorus antidotes, so-called oximes, are able to restore the enzymatic function of acetylcholinesterase (AChE) or butyrylcholinesterase (BChE) via cleavage of organophosphate from the active site of the phosphylated enzyme. In this work, the charged pyridinium oximes containing thiocarb...