Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides

The organophosphorus antidotes, so-called oximes, are able to restore the enzymatic function of acetylcholinesterase (AChE) or butyrylcholinesterase (BChE) via cleavage of organophosphate from the active site of the phosphylated enzyme. In this work, the charged pyridinium oximes containing thiocarb...

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Main Authors: Zuzana Kohoutova (Author), David Malinak (Author), Rudolf Andrys (Author), Jana Svobodova (Author), Miroslav Psotka (Author), Monika Schmidt (Author), Lukas Prchal (Author), Kamil Musilek (Author)
Format: Book
Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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