Histone deacetylase 5 regulates interleukin 6 secretion and insulin action in skeletal muscle

• Main Authors: Oleksiy Klymenko (Author), Tim Brecklinghaus (Author), Matthias Dille (Author), Christian Springer (Author), Christian de Wendt (Author), Delsi Altenhofen (Author), Christian Binsch (Author), Birgit Knebel (Author), Jürgen Scheller (Author), Christopher Hardt (Author), Ralf Herwig (Author), Alexandra Chadt (Author), Paul T. Pfluger (Author), Hadi Al-Hasani (Author), Dhiraj G. Kabra (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Physical exercise training is associated with increased glucose uptake in skeletal muscle and improved glycemic control. HDAC5, a class IIa histone deacetylase, has been shown to regulate transcription of the insulin-responsive glucose transporter GLUT4 in cultured muscle cells. In this s...