Involvement of Wiskott-Aldrich Syndrome Protein Family Verprolin- Homologous Protein (WAVE) and Rac1 in the Phagocytosis of Amyloid- β(1 - 42) in Rat Microglia

• Main Authors: Yoshihisa Kitamura (Author), Keiichi Shibagaki (Author), Kazuyuki Takata (Author), Daiju Tsuchiya (Author), Takashi Taniguchi (Author), Peter J. Gebicke-Haerter (Author), Hiroaki Miki (Author), Tadaomi Takenawa (Author), Shun Shimohama (Author)
• Format: Book
• Published: Elsevier, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alzheimer's disease (AD) is characterized by the accumulation of extracellular amyloid-β (Aβ) fibrils with microglia. Recently, there has been great interest in the microglial phagocytosis of Aβ, because the microglial pathway is considered to be one of the Aβ clearance pathways in the brain pa...