Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m6A Modification-Mediated NLRP3-Inflammasome Activation and PTEN/PI3K/Akt Signaling

• Main Authors: Bu-Hui Liu (Author), Yue Tu (Author), Guang-Xia Ni (Author), Jin Yan (Author), Liang Yue (Author), Zi-Lin Li (Author), Jing-Jing Wu (Author), Yu-Ting Cao (Author), Zi-Yue Wan (Author), Wei Sun (Author), Yi-Gang Wan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The total flavones of Abelmoschus manihot (TFA), a compound that is extracted from Abelmoschus manihot, has been widely used in China to reduce podocyte injury in diabetic kidney disease (DKD). However, the mechanisms underlying the therapeutic action of this compound have yet to be eluc...