Expanding RNA editing toolkit using an IDR-based strategy

• Main Authors: Minghui Di (Author), Junjun Lv (Author), Zhengyu Jing (Author), Yijie Yang (Author), Kunlun Yan (Author), Jianguo Wu (Author), Jianyang Ge (Author), Simone Rauch (Author), Bryan C. Dickinson (Author), Tian Chi (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

RNA base editors should ideally be free of immunogenicity, compact, efficient, and specific, which has not been achieved for C > U editing. Here we first describe a compact C > U editor entirely of human origin, created by fusing the human C > U editing enzyme RESCUE-S to Cas inspired RNA t...