A therapeutic vaccine prototype induces protective immunity and reduces cardiac fibrosis in a mouse model of chronic Trypanosoma cruzi infection.

• Main Authors: Meagan A Barry (Author), Leroy Versteeg (Author), Qian Wang (Author), Jeroen Pollet (Author), Bin Zhan (Author), Fabian Gusovsky (Author), Maria Elena Bottazzi (Author), Peter J Hotez (Author), Kathryn M Jones (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chagas disease, caused by the parasite Trypanosoma cruzi, develops into chronic Chagas' cardiomyopathy in ~30% of infected individuals, characterized by conduction disorders, arrhythmias, heart failure, and even sudden cardiac death. Current anti-parasitic treatments are plagued by significant...