A therapeutic vaccine prototype induces protective immunity and reduces cardiac fibrosis in a mouse model of chronic Trypanosoma cruzi infection.

• Үндсэн зохиолчид: Meagan A Barry (Зохиогч), Leroy Versteeg (Зохиогч), Qian Wang (Зохиогч), Jeroen Pollet (Зохиогч), Bin Zhan (Зохиогч), Fabian Gusovsky (Зохиогч), Maria Elena Bottazzi (Зохиогч), Peter J Hotez (Зохиогч), Kathryn M Jones (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Public Library of Science (PLoS), 2019-05-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Chagas disease, caused by the parasite Trypanosoma cruzi, develops into chronic Chagas' cardiomyopathy in ~30% of infected individuals, characterized by conduction disorders, arrhythmias, heart failure, and even sudden cardiac death. Current anti-parasitic treatments are plagued by significant...