Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis

• Main Authors: Antoni Olona (Author), Ximena Terra (Author), Jeong-Hun Ko (Author), Carme Grau-Bové (Author), Montserrat Pinent (Author), Anna Ardevol (Author), Ana Garcia Diaz (Author), Aida Moreno-Moral (Author), Matthew Edin (Author), David Bishop-Bailey (Author), Darryl C. Zeldin (Author), Timothy J. Aitman (Author), Enrico Petretto (Author), Mayte Blay (Author), Jacques Behmoaras (Author)
• Format: Book
• Published: Elsevier, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: When molecular drivers of healthy adipogenesis are perturbed, this can cause hepatic steatosis. The role of arachidonic acid (AA) and its downstream enzymatic cascades, such as cyclooxygenase, in adipogenesis is well established. The exact contribution of the P450 epoxygenase pathway, how...