Fibroblast growth factor-21 is required for weight loss induced by the glucagon-like peptide-1 receptor agonist liraglutide in male mice fed high carbohydrate diets

• Main Authors: Thao D.V. Le (Author), Payam Fathi (Author), Amanda B. Watters (Author), Blair J. Ellis (Author), Gai-Linn K. Besing (Author), Nadejda Bozadjieva-Kramer (Author), Misty B. Perez (Author), Andrew I. Sullivan (Author), Jesse P. Rose (Author), Laurie L. Baggio (Author), Jacqueline Koehler (Author), Jennifer L. Brown (Author), Michelle B. Bales (Author), Kaitlyn G. Nwaba (Author), Jonathan E. Campbell (Author), Daniel J. Drucker (Author), Matthew J. Potthoff (Author), Randy J. Seeley (Author), Julio E. Ayala (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Glucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RA) and fibroblast growth factor-21 (FGF21) confer similar metabolic benefits. GLP-1RA induce FGF21, leading us to investigate mechanisms engaged by the GLP-1RA liraglutide to increase FGF21 levels and the metabolic relevance of lir...