Manoalide Induces Intrinsic Apoptosis by Oxidative Stress and Mitochondrial Dysfunction in Human Osteosarcoma Cells

• Main Authors: Zhi-Kang Yao (Author), Yen-Hsuan Jean (Author), Sung-Chun Lin (Author), Yu-Cheng Lai (Author), Nan-Fu Chen (Author), Chung-Chih Tseng (Author), Wu-Fu Chen (Author), Zhi-Hong Wen (Author), Hsiao-Mei Kuo (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteosarcoma (OS) is the most common primary malignant bone tumor that produces immature osteoid. Metastatic OS has a poor prognosis with a death rate of >70%. Manoalide is a natural sesterterpenoid isolated from marine sponges. It is a phospholipase A2 inhibitor with anti-inflammatory, analgesic...